Secreted Frizzled Related Protein 4 Reduces Fibrosis Scar Size and Ameliorates Cardiac Function After Ischemic Injury
نویسندگان
چکیده
منابع مشابه
Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
A plethora of candidate genes have been identified for complex polygenic disorders, but the underlying disease mechanisms remain largely unknown. We explored the pathophysiology of type 2 diabetes (T2D) by analyzing global gene expression in human pancreatic islets. A group of coexpressed genes (module), enriched for interleukin-1-related genes, was associated with T2D and reduced insulin secre...
متن کاملimmunohistochemical analysis and role of secreted frizzled-related protein-4 in polycystic ovary-induced rat
objective: the role of wnt signaling and its antagonist; secreted frizzled related protein type 4 (sfpr4) was reported in rodent ovarian follicular development. this study examines immunolocalization of sfrp4 in ovaries of polycystic ovary (pco) rat model and evaluates its role in follicular growth arrest and its premature differentiation. materials and mathods: pco was induced with daily admin...
متن کاملSecreted frizzled-related protein-1 improves postinfarction scar formation through a modulation of inflammatory response.
OBJECTIVE The inflammatory response after myocardial infarction plays a crucial role in the healing process. Lately, there is accumulating evidence that the Wnt/Frizzled pathway may play a distinct role in inflammation. We have shown that secreted frizzled-related protein-1 (sFRP-1) overexpression reduced postinfarction scar size, and we noticed a decrease in neutrophil infiltration in the isch...
متن کاملexogenous secreted frizzled-related protein-4 modulates steroidogenesis of rat granulosa cells through wnt/bcatenin and pi3k/akt signaling pathways
background: it has been reported that secreted frizzled-related protein-4 known as an antagonist of wnt signaling pathway plays a role in luteinization process of rodent granulosa cells. the purpose of this study was twofold: 1) to determine whether recombinant human secreted frizzled-related protein-4 (rhsfrp-4) could directly induce terminal differentiation of rat granulosa cells (gcs) and 2)...
متن کاملInhibition of secreted frizzled-related protein 5 improves glucose metabolism.
Elucidating the role of secreted frizzled-related protein 5 (SFRP5) in metabolism and obesity has been complicated by contradictory findings when knockout mice were used to determine metabolic phenotypes. By overexpressing SFRP5 in obese, prediabetic mice we consistently observed elevated hyperglycemia and glucose intolerance, supporting SFRP5 as a negative regulator of glucose metabolism. Acco...
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ژورنال
عنوان ژورنال: Tissue Engineering Part A
سال: 2010
ISSN: 1937-3341,1937-335X
DOI: 10.1089/ten.tea.2009.0739